Recovery Begins Here
Call 24/7 (844) 557-8575

We’re open everyday 24/7
Get help now
Free & confidential

(844) 557-8575

Amytal Withdrawal

Amytal is a brand name for a medication called amobarbital, which is a drug used for its sedative-hypnotic properties. Amytal is in a drug category called barbiturates, which were once widely used as anxiety and sleep disorder remedies in the United States. Amytal is also in a broader category of drugs called central nervous system depressants, which work to slow down the nervous system by decreasing excitability. Like most barbiturates, Amytal is no longer widely used in the U.S. to treat common disorders involving anxiety and sleep issues. However. It’s still approved to treat anxiety and insomnia. However, if it is used today, it will most likely be to treat epilepsy. 

Though barbiturates were once popular, they were largely replaced by benzodiazepines, another depressant drug that has a safer side effects profile than barbiturates. Amytal works in the brain to suppress excitability by interacting with a natural chemical messenger called gamma-aminobutyric acid, or GABA for short. GABA binds to its receptors and slows down the nervous system, calming anxieties, decreasing alertness, and facilitating rest and sleep. 

People with sleep disorders, anxiety, and epilepsy may have some biochemical or psychological problem that prevents GABA from effectively inducing a restful state. Amytal can bind to GABA receptors on a different binding site and increase the effectiveness of the natural chemical. This can lead to sedation, hypnosis, and anxiolysis (anti-anxiety).

However, it can also lead to several adverse effects, including intoxication that’s similar to alcohol with symptoms like a lack of coordination, drowsiness, loss of motor control, slurred speech, and dizziness. Amytal was also known to cause chemical dependence and addiction when the drug used consistently for too long. Once you’re dependent on Amytal, it can cause severe withdrawal symptoms when you try to quit. In fact, Amytal can cause potentially life-threatening symptoms such as seizures and a condition called delirium tremens.

What Are Amytal Withdrawal Symptoms?

The symptoms you experience can depend on several factors, including the amount of time you’ve been dependent and whether or not you quit cold turkey. Most people experience common symptoms like anxiety, restlessness, and insomnia. Dependence can cause your body to produce more excitatory chemicals in order to counteract the drug and balance brain chemistry. 

However, Amytal will continue to suppress excitability, especially if you increase the dose over time. Then, when you stop using suddenly, your nervous system becomes over-excited until your brain chemistry can adapt and rest. 
Quitting cold turkey can cause more severe withdrawal symptoms, especially if you’ve gone through withdrawal before. A neurological phenomenon called kindling can cause more severe withdrawal symptoms with each subsequent depressant withdrawal. Other withdrawal symptoms can include:

  • Insomnia
  • Anxiety
  • Headaches
  • Nausea
  • Vomiting
  • Dizziness
  • Irritability
  • Shaking
  • Restlessness
  • Muscle twitching
  • Seizures
  • Tremors
  • Extreme confusion
  • Delirium tremens
  • Hypothermia

Seizures and delirium tremens don’t happen to everyone who goes through Amytal withdrawal. However, when they do happen, they can be deadly. Seizures can come on suddenly, causing severe injuries, which are especially dangerous if you go through them on your own. Delirium tremens is marked by extreme confusion, panic, hyperthermia, elevated blood pressure, and a fast heart rate. Without treatment, delirium tremens can lead to heart-related complications and death. 

Ready to get Help?

We’re here 24/7. Pick up the phone.

What Are the Stages in the Amytal Withdrawal Timeline?

Your withdrawal timeline depends on a few factors that involve your personal history with the drug. If you’ve been taking it for a long time, you’re used to a large dose, or if your last dose was small, it can alter your withdrawal experience. However, it’s likely that your withdrawal timeline will look something like the following:

  • One day. Your first withdrawal symptoms are likely to begin within 24 hours of your last dose of Amytal. Early symptoms are usually mild, causing symptoms like restlessness, anxiety, insomnia, and general discomfort. Symptoms may start earlier if you were used to a high dose.
  • Four days. Over the next few days, your symptoms will get worse until they reach their peak. Peak symptoms are usually the most severe. If you experience seizures and other severe symptoms, there are most likely at this phase.
  • One week. By the end of your first week, most of your symptoms will most likely disappear. However, psychological symptoms, like anxiety and depression, may linger.
  • One month. After a month, you will most likely not experience any more withdrawal symptoms, but it’s possible for symptoms like anxiety and insomnia to continue indefinitely without treatment. 

Why Should I Detox?

NCBI is the highest level of care in addiction treatment and involves 24-hour medically managed care. Not everyone who goes through addiction treatment will need to go through medical detox, but depressants like Amytal often need this medical treatment.

Hand stopping another hand from grabbing amytal pills

Since withdrawal symptoms can cause potentially life-threatening symptoms, it’s best to go through a medical detox program that can help you avoid seizures and delirium symptoms.

Detox can also help treat other medical complications and conditions you might be presenting with like heart conditions.

Medical detox is the safest way to go through Amytal withdrawal, but if you’re not sure if you need it or not, medical professionals can help you determine the right level of care for your needs. 

What is the Next Treatment Step?

If you don’t need medical detox, or if you complete it, you may go through another level of care next. After detox, the highest level of care is inpatient or residential treatment, which is reserved for people with high level medical of psychological needs. If you are able to live independently, you may go through intensive outpatient treatment or standard outpatient. Through addiction treatment, you will work through a treatment plan that’s personalized for your needs. It may involve individual, group, and family therapy, along with a myriad of other options. 

Start Your Journey to Recovery Today

If you or someone you know has been using a depressant like Amytal and might be struggling with a substance use disorder, it’s important to address the issue as soon as possible. Addiction is a serious, chronic disease that can get worse if it isn’t effectively addressed. Substance use disorders can start to affect different parts of your life, causing severe consequences like long-term health risks and strained relationships. However, addressing addiction early can help prevent some of these severe symptoms. No matter where you are in the disease of addiction, there is help available. Take your first steps toward recovery by learning more about addiction.


Becker, H. C. (1998). Kindling in Alcohol Withdrawal. Retrieved from

Center for Drug Evaluation and Research. (n.d.). Sleep Disorder (Sedative-Hypnotic) Drug Information. Retrieved from

The National Center for Biotechnology Information. Retrieved from

RXList. (n.d.). Amytal Sodium (Amobarbital Sodium Injection): Side Effects, Interactions, Warning, Dosage & Uses. Retrieved from

U.S. National Library of Medicine. (2004, September 16). gamma-Aminobutyric acid. Retrieved from

Have Questions? Call 24/7.
Calling Is Free & Confidential.

(844) 557-8575

COVID-19 Advisory: We are accepting patients and offering telehealth options. Click here for more information.